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Vasoactive intestinal peptide

Vasoactive intestinal peptide, also known as the vasoactive intestinal polypeptide or VIP, is a peptide hormone that is vasoactive. VIP is a neuropeptide of 28 amino acid residues that belongs to a glucagon/secretin superfamily, the ligand of class II G protein–coupled receptors. VIP is produced in many tissues of vertebrates including the gut, pancreas, and suprachiasmatic nuclei of the hypothalamus in the brain. VIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. In humans, the vasoactive intestinal peptide is encoded by the VIP gene.

VIP has a half-life (t) in the blood of about two minutes.