Wiktionary
prep.phr. (context idiomatic English) In a very difficult position.
Wikipedia
Up Against It is an unproduced script by Joe Orton, written in 1967 for The Beatles at the height of their fame.
Up Against It is the fifth album by West London Post punk and Indie band The Times released in 1986.
The 1912 American short film Up Against It is a romantic comedy directed by Otis Turner and starring King Baggot. It was produced by the Independent Moving Pictures (IMP) Company of New York.
As of 2012, a print of this film survives, with Dutch intertitles, in the holdings of the EYE Film Institute Netherlands in Amsterdam.
Usage examples of "up against it".
The press, hasn't got it yet, but both the British and the French are hard up against it.
That could happen here, if you were up against it, borrowed against the next harvest, and got seriously unlucky.
On Go, he pulled the door open long enough for them to each pump two gas pellets into the room, then slammed it closed again, the three of them bunching up against it as the inevitable desperate ramming began.
Whatever humanity I might conjure up against it was all factitious, and concerned my philosophy more than my feelings.
A proud-spirited young American girl might find your rules and regulations in war time rather irksome, and get up against it.