What is "trypsinogen"

Trypsinogen \Tryp*sin"o*gen\, n. [Trypsin + -gen.] (Physiol.) The antecedent of trypsin, a substance which is contained in the cells of the pancreas and gives rise to the trypsin.

n. (context biochemistry English) An inactive precursor of trypsin

n. inactive precursor of trypsin; a substance secreted by the pancreas and converted to active trypsin by enterokinase in the small intestine

Trypsinogen (EC 3.4.23.18/20/21/23/24/26) is the precursor form or zymogen of trypsin, a digestive enzyme. Produced by the pancreas, it is found in pancreatic juice, along with amylase, lipase, and chymotrypsinogen. It is activated by enteropeptidase, which is found in the intestinal mucosa, to form trypsin. Once activated, the trypsin can activate more trypsinogen into trypsin. Trypsin cleaves the peptide bond on the carboxyl side of basic amino acids such as arginine and lysine.