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TPU may refer to:

  • TACA Peru airline, ICAO code
  • Tampuon language, ISO 639-3 language code
  • Text Processing Utility, a language developed by Digital Equipment Corporation for developing text editors
  • Thermoplastic polyurethane
  • Tikapur Airport, Nepal, IATA code
  • Tomsk Polytechnic University, Tomsk, Russia
  • Troop Program Unit, an organizational component of the United States Army Reserve
  • Tensor processing unit (TPU), a custom ASIC built by Google, tailored for their TensorFlow platform