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TPF may refer to:

  • Tibial plateau fracture
  • Tactical Patrol Force, slang term for riot control squad
  • Transaction Processing Facility, an operating system by IBM
  • Terrestrial Planet Finder, a proposed system of telescopes to detect extrasolar planets
  • The Pop Factory, a Welsh television program
  • The Perl Foundation, a non-profit organization
  • The Proud Family, a Disney Channel Original Series
  • Tapered-polymer-fiber, a type of laser
  • Docetaxel, Cisplatin, and fluorouracil, a chemotherapy regimen used in head and neck cancer
  • Tokyopop, a manga publishing company
  • Telangana Praja Front, a political party
  • Tribunal pénal fédéral, the Swiss Supreme Court for criminal matters
  • Peter O. Knight Airport, IATA airport code
  • Tooting Popular Front, a fictional revolutionary organisation in Citizen Smith
  • The Purse Forum, a popular online forum dedicated to the discussion of fashion and luxury goods
  • National Treatment Purchase Fund, the Irish healthcare programme
  • Tachi Palace Fights, an American Mixed Martial Arts promotion.