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Tosco may refer to:

  • Tosco, synonym of Toscano, meaning "from Tuscany".
  • Tosco (grape), another name for the Italian wine grape Uva Tosca
  • Appennino Tosco-Emiliano National Park, a state-held natural preserve in northern-central Italy.
  • Agustín Tosco, an Argentine union leader,
  • Tosco Corporation (The Oil Shale COrporation), a U.S. oil corporation, now part of ConocoPhillips.
  • Toscotec, an Italian company
  • TOSCO II process, a shale oil extraction technology
  • MV Tosco, an Italian coastal tanker