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The Collaborative International Dictionary
To tire out

Tire \Tire\, v. t. To exhaust the strength of, as by toil or labor; to exhaust the patience of; to wear out (one's interest, attention, or the like); to weary; to fatigue; to jade.
--Shak.

Tired with toil, all hopes of safety past.
--Dryden.

To tire out, to weary or fatigue to exhaustion; to harass.

Syn: To jade; weary; exhaust; harass. See Jade.