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TME may refer to:

  • Trimethylolethane, a high performance polyol containing three primary hydroxyl groups
  • TME (psychedelics), a series of psychedelic drugs
  • Total mesorectal excision, a standard technique for treatment of colorectal cancer
  • Transmissible mink encephalopathy, a rare disease that affects ranch-raised mink
  • TME, Transaction Machine Environment, a defunct computer operating system made by International Computers Limited (ICL)
  • Toyota Motor Europe, Toyota's regional headquarters in Europe.
  • TME, "Technical Marketing Engineer," a descriptive job title used in the computer software industry
TME (psychedelics)