Crossword clues for thyroglobulin
Wiktionary
n. (context protein English) A globulin, produced by the thyroid gland, that has a role in the production of the thyroid hormones
WordNet
n. an iodine containing protein that is obtained from the thyroid gland and exhibits the general properties of the globulins
Wikipedia
Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin protein accounts for approximately half of the protein content of the thyroid gland.
The protein is a precursor of the thyroid hormones; these are produced when thyroglobulin's tyrosine residues are combined with iodine and the protein is subsequently cleaved. Each thyroglobulin molecule contains approximately 100-120 tyrosine residues, but only a small number (20) of these are subject to iodination by thyroperoxidase in the follicular colloid. Therefore, each Tg molecule forms only approximately 10 thyroid hormone molecules.
Usage examples of "thyroglobulin".
At need, the thyroxine content of the thyroglobulin is stripped off and sent out into the bloodstream.
A chemical regulator related to thyroglobulin was no longer suppressed.
However, thyroglobulin is a large protein molecule, possessing a molecular weight, we now know, of up to 700,000.
For this reason it quickly seemed clear that thyroglobulin was at best merely the stored form of the hormone, and that what passed into the bloodstream were small fragments of the thyroglobulin molecule.
Preparations of thyroglobulin itself were 30 times or so as rich in iodine as was the intact thyroid gland and contained up to almost i per cent iodine.
The thyroxine molecules are then united with other, more common amino acids and stored as the large thyroglobulin molecule.