What is "thioperamide"

n. A potent histamine antagonist that crosses the blood-brain barrier.

Thioperamide is a potent HRH antagonist and selective HRH antagonist capable of crossing the blood–brain barrier. It was used by Jean-Charles Schwartz in his early experiments regarding the H receptor. Thioperamide was found to be an antagonist of histamine autoreceptors, which negatively regulate the release of histamine, and enhances the activity of histaminergic neurons by blocking autoreceptors, leading to greater release of histamine.