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Trichohyalin is a protein in humans that is encoded by the TCHH gene.

Trichohyalin confers mechanical strength to the hair follicle inner root sheath and to other toughened epithelial tissues, such as the hard palate and filiform ridges of the tongue, by forming multiple complex crosslinks with itself and with other structural proteins (Steinert et al., 2003 [PubMed 12853460]).[supplied by OMIM, Dec 2009]. The enzyme converts arginine to citrulline at the inner root sheath and medulla of hair follicles.