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TBE can refer to:

  • Tick-borne encephalitis
  • TBE buffer, a buffer solution that consists of a mixture of tris base, boric acid, EDTA, and water
  • Teledyne Brown Engineering
  • Tetrabromoethane, a dense liquid used for mineral separation
  • Tribromoethanol, an anesthetic agent with dangerous side effects
  • To be elected, acronym
  • The Black Eyed Peas, an American hip-hop group
  • Toronto Board of Education (TBE), a defunct school district
  • Episodes of The Blacklist
  • The Best Ever, shortened to TBE, one of the nicknames of Floyd Mayweather, Jr.