What is "streptazolin"

Streptazolin is an antibiotic and antifungal substance isolated in 1981 from Streptomyces viridochromogenes.

Because of its polymerisation tendency, it is not suitable for therapeutic use. 1,4- reduction of the conjugated diene gives dihydrostreptazolin which is stable, but has very limited antimicrobial properties.

The first total synthesis of ( racemic) streptazolin was achieved in 1985 with the aid of a modified Ferrier rearrangement.