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SSSS can refer to:

  • Scandinavian Simvastatin Survival study was one of the earliest studies on the effect of lowering human plasma cholesterol by pharmacological means
  • Secondary Security Screening Selection, a code used by airlines on boarding cards of passengers selected for secondary security screening
  • In Representational State Transfer, Server Side Session State, in contrast to CSSS (Client Side Session State)
  • Society for Social Studies of Science, a professional organization more commonly abbreviated 4S
  • Society for the Scientific Study of Sexuality
  • In dermatology and neonatology, Staphylococcal scalded skin syndrome, a severe exfoliative skin reaction caused by a Staphylococcus aureus exotoxin
  • Superhuman Samurai Syber-Squad, a children's television show based on Denkou Choujin Gridman
  • For its use as a Serbian political slogan, see CCCC (disambiguation)
  • Shamir's Secret Sharing Scheme, is a Secret sharing software based on Polynomial interpolation
Ssss Music album by duo VCMG – Vince Clarke and Martin Gore - released in 2012