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SPZ may refer to:

  • sporadic permafrost zone, see Permafrost.
  • subparaventricular zone, a region of the hypothalamus critically involved in sleep/wake regulation
  • Silver Springs Airport, Nevada, USA - FID code SPZ
  • Springdale Municipal Airport, Arkansas, USA - IATA code SPZ
  • SPZ Group, owner of Sarm West Studios music company