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SPX can refer to:

  • Sequenced packet exchange, part of the IPX/SPX protocol suite.
  • A file extension used for Speex-encoded audio files
  • S&P 500 index ticker
  • Superphénix, a nuclear power plant
  • Small Press Expo, an alternative comics convention
  • Sports Performance eXtreme, a sports shoe and clothing brand
  • St Pius X College, Sydney, Australia
  • St. Pius X Seminary, Roxas City, Philippines
  • St. Pius X, the 257th Pope of the Roman Catholic Church.
  • SPX Corporation, a Fortune 500 electronics company
  • The National Rail code for St Pancras International railway station in Greater London
  • The former IATA and FAA code for Houston Gulf Airport