SPW may refer to:
- Students Partnership Worldwide, an international development charity specialising in youth-to-youth education
- The Schützenpanzerwagen, SdKfz 251, an armoured fighting vehicle built by Germany during World War II
- The Socialist Party of Washington, a state affiliate of the Socialist Party of America established in 1901
- SPX Corporation, based on its symbol on the New York Stock Exchange, SPW.
- St Peter's Woodlands Grammar School, a co-educational Anglican primary school located in Adelaide, South Australia.
- Semi Precious Weapons, an American glam rock band.
- The IATA code for Spencer Municipal Airport, a public airport in Spencer, Iowa.
- Sexuality Policy Watch, a global activist and research forum on sexuality, policies and politics; based in Brazil.
- SPW, the SAME code for a shelter in place warning.