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SPSE can refer to:

  • Société du pipeline sud-européen, operator of a crude oil pipeline in France, Switzerland and Germany
  • Society of Photographic Scientists and Engineers, a former name for the Society for Imaging Science and Technology (IS&T)
  • Society of Professionals, Scientists and Engineers, union representing some University of California staff at the Lawrence Livermore National Laboratory
  • South Pacific Stock Exchange, a stock exchange based in Suva, Fiji
  • Southern Pump Services Engineering, pump manufacturer in Perivale, United Kingdom
  • Syndicat du personnel de soutien en éducation, labour union that forms part of the Centrale des syndicats du Québec in Canada
  • Sistem Pengadaan Secara Elektronik, a nationwide Electronic Government Procurement System of Government of Indonesia