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SPPS can refer to:

  • Saint Paul Public Schools
  • Solid phase peptide synthesis
  • Solution precursor plasma spray
  • Steam Powered Preservation Society
  • South Park Primary School, a primary school in London, United Kingdom
  • Scandinavian Plant Physiology Society
  • Social Psychological and Personality Science, a quarterly academic journal for social and personality psychology-related topics
  • Spectral Parameter Power Series, a method for solving Sturm-Liouville equations
  • Super Proton Synchrotron, an accelerator at CERN, was referred to as the SpS when it collided protons and anti-protons.