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SPOC is an acronym that may stand for:

  • Single Point of Contact
  • Sex Professionals of Canada, a sex workers' rights group based in Toronto
  • Sydney Paralympic Organising Committee, responsible for the 2000 Summer Paralympics
  • Simple Piece of Cloth, a type of baby sling
  • Small private online course, a version of a MOOC (Massive Open Online Course) used locally with on-campus students.