What is "spiperone"

n. (context organic compound medicine English) A psychoactive drug structurally related to butyrophenone

Spiperone (Spiroperidol; brand name: Spiropitan ( JP)) is a typical antipsychotic and research chemical belonging to the butyrophenone chemical class. It is licensed for clinical use in Japan as a treatment for schizophrenia. Additionally, spiperone was identified by compound screening to be an activator of Ca activated Cl channels (CaCCs), thus a potential target for therapy of cystic fibrosis.

Receptor

K (nM)

Notes

5-HT

17.3

5-HT

995

5-HT

2397

5-HT

5051

5-HT

3.98

5-HT

1.17

5-HT

1114.2

5-HT

922.9

5-HT

>10000

No data available from
cloned human receptors.
Data comes from rat cortex
receptors and other sources.

5-HT

2512

Cloned mouse receptor.

5-HT

1590

Cloned rat receptor.

5-HT

109.8

α

20.4

α

3.09

α

8.32

D

398.5

D

0.16

D

0.34

D

1.39

D

4500

H

272

σ

353

N-Methylspiperone (NMSP) is a derivate of spiperone that is used to study the dopamine and serotonin neurotransmitter system. Labeled with the radioisotope carbon-11, it can be used for positron emission tomography.