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Speirs is a surname. Notable people with the surname include:

  • Annie Speirs (1889–1926), British freestyle swimmer
  • Fraser Speirs (21st century), Glasgow-based harmonica player
  • Gardner Speirs (born 1963), Scottish former footballer and manager
  • Jimmy Speirs (1886–1917), Scottish football player
  • Nicole Speirs (born 1983), domestic violence murder victim
  • Ronald Speirs (1920–2007), United States Army officer
  • Steve Speirs (born 1965), British actor
  • William Speirs Bruce (1867–1921), London-born Scottish polar scientist and oceanographer