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SPAP may refer to:

  • School of Pure and Applied Physics at Mahatma Gandhi University
  • Piraeus, Athens and Peloponnese Railways, a meter-gauge railway network in southern Greece
  • Secure Password Authentication Protocol
  • Shiva Password Authentication Protocol
  • The Independent Anti-terrorist Police Subunits of the Polish police; see Policja#Anti-terrorist forces (BOA/SPAP)
  • systolic pulmonary artery pressure (sPAP); see Pulmonary hypertension#Diagnosis
  • State Prescription Assistance Program, social program prescription assistance offered in U.S. states; see Medicaid#State implementations