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Longman Dictionary of Contemporary English
soul-destroying
adjective
EXAMPLES FROM OTHER ENTRIES
▪ Going to the unemployment office and having to wait there for hours is a soul-destroying experience.
▪ Most people are unaware of the back-breaking, soul-destroying labor required in past centuries.
▪ They spend all day sticking paper labels on toy cars - it's soul-destroying.
EXAMPLES FROM CORPUS
▪ A soul-destroying activity and one calculated to make any cat lower its personal standards.
▪ He could remember every dismal dreary moment of it, with soul-destroying clarity.
▪ It was soul-destroying to him but it gave him money for his wife and child.
▪ Nothing is more soul-destroying than being completely dependent on another person.
Wiktionary
soul-destroying

a. Causing erosion of moral fortitude or that eliminates hope or motivation

WordNet
soul-destroying

adj. destructive to the spirit or soul; "soul-destroying labor"

Usage examples of "soul-destroying".

She poured into Rhyssa's mind the jumble of pain/despondency/anguish/guilt, the self-accusation, and the soul-destroying terror that Peter had been en during.

She would forget the heated, soul-destroying pleasure he had given her and content herself with the life that had been planned for her.

It is one thing to preserve a hatred for the killing machines and the soul-destroying machines and the garbage-making machines.