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The acronym SMO may refer to:

  • Senior Medical Officer
  • Sequential Minimal Optimization, a fast method to solve huge quadratic programming problems, widely used to speed up the training of the Support Vector Machines (SVMs)
  • Singapore Mathematical Olympiad, a mathematics competition
  • Saturday Morning Orchestra, an amateur orchestra based in the south of England. Established in 1971 and named after its rehearsal time.
  • Site Management Organization, a person or an organization that enters into a contract with a pharmaceutical company or a contract research organization to assume the responsibilities of a clinical investigator
  • Sliding mode observer, a state observer that uses discontinuous sliding mode control to achieve finite-time zero estimator error in at least one dimension
  • Smo, a is used to describe a person, often wealthy men who are less muscular and weaker than bodybuilders, who pays bodybuilders money for private posing sessions, wrestling, and prostitution.
  • Social media optimization
  • Social movement organization
  • Solar Monitoring Observatory, a space science observatory for the International Space Station
  • Survey and Mapping Office, an office of the Lands Department is the central authority for land surveys and all types of mapping in Hong Kong
  • SQL Server Management Objects, a collection of objects through which programs can manage Microsoft SQL Server
  • the International Air Transport Association code for Santa Monica Airport in the United States
  • the Samoan language code