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SMAC may refer to:

  • Scrum Master Accredited Certification, a certification from to manage Agile methodology based projects and actions
  • Sabang Merauke Raya Air Charter, an Indonesian airline
  • Second mitochondria-derived activator of caspases or Diablo homolog, a component of the apoptosis pathway
  • Sequential Multiple Analysis - Computer or comprehensive metabolic panel, a panel of clinical chemistry lab tests
  • Sid Meier's Alpha Centauri, a computer game
  • Southern Maryland Athletic Conference
  • Southwestern Michigan Athletic Conference
  • Stone Mountain Arts Center, an arts center in Brownville, Maine, United States, North America
  • Supramolecular activation cluster, the structure comprising the immunological synapse
  • Simulation Model of Automobile Collisions
  • Supreme Macedonian-Adrianople Committee
  • Social Mobile Analytics Cloud, also known as Third platform
  • Social Media Advertising Coin
  • Social Media Advertising Consortium