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SJS may refer to:

  • San Jacinto Seminary, a minor seminary in the Philippines
  • San Jose Sharks, a professional ice hockey team based in San Jose, California, United States
  • Sarah Jane Smith, a fictional character in the Doctor Who universe
  • Scientific jury selection, the use of social science techniques and expertise to choose favorable juries
  • Shanghai Japanese School
  • Special Judicial Squad, a fictional organization in the Judge Dredd comic book universe
  • St. John's School (Texas), a coeducational independent school in Houston, Texas, United States
  • Stevens–Johnson syndrome, a life-threatening condition affecting the skin
  • Sun Java System, a brand used by Sun Microsystems to market computer software
  • Swyer-James Syndrome, a manifestation of postinfectious obliterative bronchiolitis
  • Student Job Search, a nonprofit organization that helps tertiary students studying in New Zealand find employment