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sickle cell anaemia

alt. (context pathology British English) A severe hereditary form of anaemia, mainly affecting people of African origin, in which mutated haemoglobin distorts red blood cells into a crescent shape, causing the cells to become stuck in capillary. Downstream tissues are thus deprived of oxygen causing ischaemia and infarction. n. (context pathology British English) A severe hereditary form of anaemia, mainly affecting people of African origin, in which mutated haemoglobin distorts red blood cells into a crescent shape, causing the cells to become stuck in capillary. Downstream tissues are thus deprived of oxygen causing ischaemia and infarction.