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Shin-Yakushi-ji

is a Buddhist temple of the Kegon sect in Nara, Japan. It was founded in 747 by Empress Kōmyō. Initially a large complete Shichidō garan temple, it suffered from fire damage and deteriorated during the Heian period. The temple was revived during the Kamakura period. Only one building, the present main hall or , has survived from the 8th century. All other structures date to the Kamakura period.

Shin-Yakushi-ji owns several cultural assets. The Hon-dō, the principal image of Yakushi Nyorai and eleven statues of the Twelve Heavenly Generals have been designated by the Ministry of Education, Culture, Sports, Science and Technology of the government of Japan as National Treasures.