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Sharpless
  • Sharpless asymmetric dihydroxylation, a chemical reaction
  • Sharpless catalog, a 20th-century astronomical catalog with 313 items
  • Sharpless epoxidation, a chemical reaction
  • Sharpless oxyamination, a chemical reaction
  • Bevan Sharpless, astronomer
  • Karl Barry Sharpless, an American chemist
  • Josh Sharpless, baseball player
  • Stewart Sharpless, astronomer
  • Isaac Sharpless, educator
  • A character in Madama Butterfly