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SFN may refer to:

  • Short filename, the 8.3 filename limitation of the DOS computer operating system
  • SFN Group, Inc., a North American temporary work agency
  • Single-frequency network, a broadcast network where several transmitters simultaneously send the same signal over the same frequency channel
  • Society for Neuroscience, a professional society headquartered in Washington, D.C.
  • Subcutaneous fat necrosis of the newborn, a medical condition occurring in newborns
  • Protein stratifin