Serle is a comune in the province of Brescia, in Lombardy, Italy. It is bordered by the neighboring communes of Nuvolento, Caino and Botticino.
Serle is a surname, and may refer to:
- Ambrose Serle (1742–1812), British diarist
- John Serle (disambiguation)
- Percival Serle, Australian biographer
- William Serle (1912–1992), Scottish ornithologist, physician, and minister