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Sepe may refer to:

  • Sepe (surname)
  • Sepé Tiaraju, Brazilian Guaraní tribe leader
  • Sepe, a form of Kurdish dance
  • São Sepe River, Brazilian river
  • São Sepé, Brazilian town
Sepe (surname)

Sepe is a surname. Notable people with the surname include:

  • Michele Sepe, Italian rugby player
  • Crescenzio Sepe, Italian cardinal
  • Daniele Sepe, Italian musician
  • Frank Sepe, American fitness author
  • Luigi Sepe, Italian footballer
  • Majda Sepe, (1937–2006) Slovenian singer