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Seoane is a toponymic surname. It may refer to:

  • Consuelo Seoane (1876–1964), colonel in the US Army (third cavalry)
  • Diego Seoane Pérez (born 1988), Spanish footballer
  • Fernando Seoane (born 1983), Spanish professional footballer
  • Gerardo Seoane (born 1978), Swiss footballer
  • Luís Seoane (1910–1979), lithographer and artist
  • Manny Seoane (born 1955), retired professional baseball player
  • Manuel Seoane (1902–1975), Argentine football striker
  • Mariana Seoane (born 1976), Mexican actress, model and singer