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Semmes may refer to:

  • Semmes, Alabama, a community in southwest Alabama
  • Alexander Alderman Semmes (1825-1885), American Civil War Union Navy commodore.
  • Benedict J. Semmes, Jr. (1913-1994), United States Navy admiral
  • Benedict Joseph Semmes (1789–1863), American politician and Maryland State Senator
  • Bernard B. Semmes, a mayor of Newport News, Virginia
  • Paul Jones Semmes (1815–1863), a banker, businessman, and a Confederate General in the American Civil War
  • Raphael Semmes (1809–1877), an officer in both the U.S. Navy and Confederate Navy
  • Stephen Semmes, a Professor of Mathematics at Rice University
  • Thomas J. Semmes (1824–1899), a member of the Louisiana state legislature
  • T. Semmes Walmsley (1889–1942), Mayor of New Orleans
  • , more than one United States Navy ship