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Sefro is a comune (municipality) in the Province of Macerata in the Italian region Marche, located about southwest of Ancona and about southwest of Macerata. As of 31 December 2004, it had a population of 453 and an area of .

Sefro borders the following municipalities: Camerino, Fiuminata, Pioraco, Serravalle di Chienti.