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SDSS may refer to:

  • Sloan Digital Sky Survey, a major multi-filter imaging and spectroscopic redshift survey
  • Social Democratic Party of Slovakia
  • Spatial Decision Support System, a GIS based decision aiding system
  • Independent Democratic Serb Party, a political party of Croatian Serbs (Samostalna demokratska srpska stranka in Serbian and Croatian)
  • South Delta Secondary School, a school in Delta, British Columbia, Canada