SDB or sdb may refer to:
- Safe deposit box, a type of safe
- Saldanha Bay Airport, South Africa
- Schiller-Duval body, a pathologic finding pathognomonic for endodermal sinus tumors (yolk sac tumors)
- Sir Donald Bradman (1908-2001), Australian cricketer
- Subdwarf B star (SdB)
- Sleep Disorder Breathing
SDB is a symbolic debugger for C programs. It may be used to examine their files and to provide a controlled environment for their execution. SDB was first introduced in UNIX/32V.