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SCRIB

SCRIB, also known as Scribble, SCRIBL, or Scribbled homolog (Drosophila), is a scaffold protein which in humans is encoded by the SCRIB gene. It was originally isolated in Drosophila melanogaster in a pathway (also known as the Scribble complex) with DLGAP5 (Discs large) and LLGL1 (Lethal giant larvae) as a tumor suppressor. In humans, SCRIB is found as a membrane protein and is involved in cell migration, cell polarity, and cell proliferation in epithelial cells. There is also strong evidence that SCRIB may play a role in cancer progression because of its strong homology to the Drosophila protein.

Usage examples of "scrib".

Scribner was an artist of some ability, and she made several little sketches of the vine on whitewood paper cutters as gifts to her friends.

Khidhir Hamza with Jeff Stein, Saddam's Bombmaker (New York: Scribner, 2000), pp.

Letter of this date says that editor at Scribner 's liked Young Atomic Engineers.

In June of 1999, I decided to spend the summer finishing the damn writing book - let Susan Moldow and Nan Graham at Scribner decide if it was good or bad, I thought.