Wiktionary
vb. 1 To fiddle with; to tinker. 2 To mess with; to have on; to trick.
Usage examples of "screw with".
You were the officer of the watch, boy, and if you have any desire to stay an officer on this ship, I suggest you establish clear understandings with the duty officer of each watch, that you take threats against this ship damned seriously, that you don't screw with the guard I've put on our accesses, because I don't take for granted that woman won't try to slip us a bomb in one of the cans or walk onto this ship armed, do you hear me?
Scotty bent and finished removing the first screw with his fingers.
If they had wives and kids, I'm sorry about that, but when you screw with people, you need to understand that they're going to come see you about it.
But we establish his connection to Tubbs, let him think one of his customers is trying to screw with him.