saopaulo Largest Southern Hemisphere city Home to millions of Brazilians Two-time host city of the FIFA World Cup State capital on the Tietê River South American state capital city Most populous Southern Hemisphere city Metropolis in Brazil Biggest city in South America Brazil's biggest city State capital on the TietГЄ River Caesar Park International Airport site Brazil's largest city 2014 World Cup host Brazilian city or state Largest city in South America South America's largest city