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Ruysch is the surname of several persons:

  • Frederik Ruysch (1638—1731), Dutch doctor and anatomist, remembered for his developments in anatomical preservation and the creation of dioramas or scenes incorporating human parts
  • Johannes Ruysch (c. 1460?, Utrecht - 1533, Cologne), a.k.a. Johann Ruijsch or Giovanni Ruisch, explorer, cartographer, astronomer, manuscript illustrator and painter from the Low Countries
  • Rachel Ruysch (1664—1750), Dutch artist who specialized in still-life paintings of flowers, daughter of Frederik Ruysch