Rufo may refer to:
- San Rufo, village and comune in southern Italy.
- Antonio Gómez Rufo, Spanish writer
- Robert Rufo, American jurist and politician.
- RUFO - Rights Upon Future Offers
Rubén Herráiz Alcaraz (born 13 January 1993), commonly known as Rufo, is a Spanish footballer who plays for RCD Espanyol B as a forward.