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RME may refer to:

  • RME Audio, a German audio company
  • Rapeseed Methyl Ester, a form of biodiesel
  • Realistic Mathematics Education, a system of math teaching originally from the Netherlands
  • Receptor-mediated endocytosis, a biological process
  • Rich Media Environment, an Open Mobile Alliance standard for broadcasting multimedia content
  • Ronsdorf-Müngstener Eisenbahn
  • Religious and Moral Education
  • Rack-Mounted Equipment
  • Responsible Managing Employee, a supervisory employee holding a required license or certification
  • River Music Experience, in Davenport, Iowa
  • IATA Airport Code for Griffiss International Airport in Rome, New York