n. A bactericidal antibiotic, primarily used in the treatment of tuberculosis, whose effect is based on blocking the DNA-dependent RNA-polymerase of the bacteria.
Rifabutin (Rfb) is a bactericidal antibiotic drug primarily used in the treatment of tuberculosis. The drug is a semi-synthetic derivative of rifamycin S. Its effect is based on blocking the DNA-dependent RNA-polymerase of the bacteria. It is effective against Gram-positive and some Gram-negative bacteria, but also against the highly resistant mycobacteria, e.g. Mycobacterium tuberculosis, M. leprae, and M. avium intracellulare.
Rifabutin is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.