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RGD may refer to:

  • RGD, the abbreviation for Arginylglycylaspartic acid
  • RGD-5, a Soviet/Russian hand grenade
  • RGD-33, a Soviet WWII-era hand grenade
  • The Association of Registered Graphic Designers of Ontario or the related professional designation of Registered Graphic Designer
  • Rat genome database, a collection of genetic and genomic information about the rat
  • The Reacting Gas Dynamics Laboratory at the Massachusetts Institute of Technology
  • Registrar General Department, a government agency responsible for civil registration in many Commonwealth countries