RDE may refer to:
- Redundant data elimination, the process of reducing file storage requirements through data deduplication
- Revue d'Égyptologie, a scholarly journal of Egyptology (commonly abbreviated RdE)
- Rotating disk electrode, a type of electrode used in electrochemistry
- Rule-developing experimentation, a term used in market research
- European Democratic Alliance (Rassemblement des Démocrates Européens), a political group in the European Parliament 1984–1995.