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qpsmtpd is an SMTP daemon written in Perl. It was originally designed to be a drop-in replacement for qmail-smtpd, the SMTP component of qmail, and it is now also compatible with Postfix, Exim, sendmail and virtually any software that "speaks SMTP". It has a flexible plugin system, making it easy to interoperate with other pieces in a mail system.

Its main purpose is to allow mail administrators to perform more advanced spam filtering than is possible with other SMTP daemons. As one example of dozens, the earlytalker plugin blocks many viruses and mass mailers based on their characteristic violation of basic protocol, even before they start sending mail data.

The program's main author is Ask Bjørn Hansen. It is licensed under the MIT License.