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The initialism PVL may refer to:

  • Periventricular leukomalacia, the death of brain tissue, caused by lack of oxygen
  • Proliferative verrucous leukoplakia, a condition in the oral mucosa
  • Parameter Value Language, the data markup language, used by NASA
  • Panton-Valentine leukocidin, a factor in bacterial virulence
  • The paleontological collection of the Fundación-Instituto Miguel Lillo, Universidad Nacional de Tucumán
  • Pioneer Valley League, a high school athletic conference in Massachusetts
  • Program Validation Limited, a British company that developed SPARK
  • The Pascack Valley Line, a commuter rail line operated by NJ Transit
  • Peter Van Loan, a Canadian politician
  • The Old Russian Primary Chronicle
  • Pike County Airport in Pikeville, Kentucky, IATA Code