What is "purinosome"

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The color scheme is as follows: enzymes, coenzymes, substrate names, metal ions, inorganic molecules ]]

The purinosome is a putative multi-enzyme complex that carries out de novo purine biosynthesis within the cell. It is postulated to include all six of the human enzymes identified as direct participants in this ten-step biosynthetic pathway converting phosphoribosyl pyrophosphate to inosine monophosphate:

Step(s)

Symbol

Description

1

PPAT

phosphoribosylpyrophosphate amidotransferase

2,3,5

GART

trifunctional phosphoribosylglycinamide formyltransferase/phosphoribosylglycinamide synthetase/phosphoribosylaminoimidazole synthetase

4

PFAS

phosphoribosylformylglycinamidine synthase

6,7

PAICS

bifunctional phosphoribosylaminoimidazole carboxylase

8

ADSL

adenylosuccinate lyase

9,10

ATIC

bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase